Basic Information
VIS ID
TVIS10004974
Fusion event
HBV-chr22 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1869
Orient
-
Integrated sequence
GTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGC| |CTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTTCTGACTTC
Host Sequence
Chromosome
chr22
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
23210834/22868655 (Hg38)
End
23210834/22868655 (Hg38)
Orient
-
Location type
Intronic
Target gene
IGL ; LOC105372948
Nearest miRNA
hsa-mir-1286/Upstream/45784; hsa-let-7a-3/Downstream/17612;
Nearest TSS
ENST00000624155/Upstream/10630; ENST00000390318/Downstream/2852;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/223912, chr22-CpG: 142/Downstream/201390
Junction sequence
TTGGTCTGTTCACCAGCACCATGCAACCAA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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