Basic Information
VIS ID
TVIS10004983
Fusion event
HBV-chr3 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2339
Orient
-
Integrated sequence
ACTGTTCTTGAGTATTTGGTGTCTTTTGGAGTGTGGATTCGCACTCCTCCCGCTTACAGACCACCAAATGCCCCTATCTTATCAACACTTCCGGAAACTA| |CTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGA
Host Sequence
Chromosome
chr3
Cytoband
q13.31
Reference genome
GRCh37/hg19
Start
113666494/113947647 (Hg38)
End
113666494/113947647 (Hg38)
Orient
+
Location type
Promoter
Nearest miRNA
hsa-let-7g/Upstream/352705; hsa-mir-12124/Downstream/368828;
Nearest TSS
ENST00000440867/Upstream/77; ENST00000491556/Downstream/254;
Nearest CpG islands
chr3-CpG: 124/Target, None/Upstream, None/Downstream
Nearby gene
GRAMD1C(-473) ; ZDHHC23(+254) ;
Upstream sequence
ttcatgtgtttataaaatgcaactaatgtatcaaacctgtgatttccaggacataattacttaagctaaggaaaaaagaaaacatgagtgaaggaaaaac
Downstream sequence
AccggcgcgccgcccgcaggcaccggcggcgcccggcTGCCGCCTCTggggcggggcggggcgtggcgtggcggggcaggccggAGGTGCGGGACCCACC
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate