Basic Information
VIS ID
TVIS10004989
Fusion event
HBV-chr3 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
256
Orient
-
Integrated sequence
GGAGAGCACAACATCAGGATTCCTAGGACCCCTGCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCACAGAGTCTAGACTCG| |TGGTGGACTTCTCTCAATTTTCTAGGGGGAGCACCCACGTGTCCTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAA
Host Sequence
Chromosome
chr3
Cytoband
q25.33
Reference genome
GRCh37/hg19
Start
159160140/159442351 (Hg38)
End
159160140/159442351 (Hg38)
Orient
-
Location type
SCHIP1,intron IQCJ-SCHIP1,intron
Fragile sites / regions
FRA3D
Target gene
IQCJ-SCHIP1 ; SCHIP1
miRNAs that regulate target gene
hsa-mir-98-5p
Nearest miRNA
hsa-let-7g/Upstream/159617; hsa-mir-1224/Downstream/962237;
Nearest TSS
ENST00000440867/Upstream/168596; ENST00000639448/Downstream/321362;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/639811, chr3-CpG: 166/Downstream/320806
Upstream sequence
tttttgtagagatgcggtttcgtcatgttgcccaggctggtctcagacacctgggctcaagtgctcttccaggctcagcctcacaaagtgctgggattat
Downstream sequence
AGTCTGGTCAGGATAGGAGCGCTCCAACCTTTGTTTCTGTCCCCTATCATGTGTTGGAGATCCAGAGTCTAGGAGGATGACACCCAGCTGGCTGAGCTTA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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