MAP3K13 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10004992
Fusion event
HBV-MAP3K13 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2358
Orient
-
Integrated sequence
TGTCTTTTGGAGTGTGGATTCGCACTCCTCCCGCTTACAGACCACCAAATGCCCCTATCTTATCAACACTTCCGGAAACTACTGTTGTTAGACGACGAGG| |CAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATCCC
Host Sequence
Chromosome
chr3
Cytoband
q27.2
Reference genome
GRCh37/hg19
Start
185015882/185298094 (Hg38)
End
185015882/185298094 (Hg38)
Orient
-
Location type
Intron
Fragile sites / regions
FRA3C
Target gene
MAP3K13
miRNAs that regulate target gene
hsa-mir-93-5p ; hsa-mir-203a-3p ; hsa-mir-129-5p ; hsa-mir-153-5p ; hsa-mir-3978 ; hsa-mir-589-3p ; hsa-mir-6760-3p ; hsa-mir-6835-3p ; hsa-mir-7850-5p
Nearest miRNA
hsa-let-7g/Upstream/44822; hsa-mir-1248/Downstream/469753;
Nearest TSS
ENST00000440867/Upstream/12701; ENST00000428617/Downstream/30794;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/14986, chr3-CpG: 71/Downstream/200428
Upstream sequence
TGACAGAAAGGAAGGTCAGAAGGCCAAATGGCTTCAAGCCCTCAAAATATCCTTCCATTGCTTTGTAGTGAAGCTCTGGCCTTTGCTGCTGATCTCACTT
Downstream sequence
AAGCTGGTATTTTTGAGGCAAAAGATAAGAATATTTAGCTAAATGGTGTTCCACTTGCAAAATGTGCTAGTTCTTATTTGATTTTTTTCTTCTTTCTTAG
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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