ALB _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005005
Fusion event
HBV-ALB integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1801
Orient
+
Integrated sequence
CATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTG| |TTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCA
Host Sequence
Chromosome
chr4
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
74270318/73404601 (Hg38)
End
74270318/73404601 (Hg38)
Orient
+
Location type
Intron
Target gene
ALB
miRNAs that regulate target gene
hsa-mir-492
Nearest miRNA
hsa-mir-12113/Upstream/7127673; hsa-mir-1243/Downstream/3168967;
Nearest TSS
ENST00000502981/Upstream/293; ENST00000507673/Downstream/4037;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/145188, chr4-CpG: 20/Downstream/215726
Upstream sequence
AGTTTTCAACAGCATTTAATACAGGTTATAACACTCTTAATTACAAAGACTTTTTCTTTTCTTAATACTCTGTTGATTTTCCTCTTATGTAACTGAATAT
Downstream sequence
CAGAATTGTTTAGTGACTGTAATTTTCTTTTGCGCACTAAGGAAAGTGCAAAGTAACTTAGAGTGACTGAAACTTCACAGAATAGGGTTGAAGATTGAAT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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