VISDB Viral Integration Site DataBase

VIS ID

TVIS10005028

Fusion event

HBV-ARSK integration

Validated

No

Detection method

PCR and Ultra-deep sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Start

373

Orient

-

Integrated sequence

TTTTCTAGGGGGAGCACCCACGTGTCCTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAATTTGTCCTGGCTATCGC| |TGGATGTGTCTGCGGCGTTTTATCATATTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTACCAAGGTATGTTGCCCGTTT

Chromosome

chr5

Cytoband

q15

Reference genome

Start

End

94891684/95555980 (Hg38)

Orient

-

Location type

ARSK,intron TTC37,promoter

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-10a-5p ; hsa-mir-10b-5p ; hsa-mir-190a-3p ; hsa-mir-556-3p ; hsa-mir-2681-5p ; hsa-mir-5011-5p ; hsa-mir-5693 ; hsa-mir-6842-3p ; hsa-mir-4639-5p ; hsa-mir-6885-3p ; hsa-mir-5585-3p ; hsa-mir-3163 ; hsa-mir-8087 ; hsa-mir-6739-5p ; hsa-mir-7150 ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-4736 ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-6077 ; hsa-mir-9500 ; hsa-mir-5584-5p ; hsa-mir-8080 ; hsa-mir-6873-5p ; hsa-mir-127-5p ; hsa-mir-7843-3p ; hsa-mir-7848-3p ; hsa-mir-6806-3p ; hsa-mir-3928-5p ; hsa-mir-656-3p ; hsa-mir-208b-5p ; hsa-mir-208a-5p ; hsa-mir-504-5p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-7977 ; hsa-mir-6802-5p ; hsa-mir-654-5p ; hsa-mir-541-3p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-3135a ; hsa-mir-383-3p ; hsa-mir-6865-5p ; hsa-mir-6815-5p ; hsa-mir-450a-5p ; hsa-mir-4737 ; hsa-mir-6514-3p ; hsa-mir-6847-3p ; hsa-mir-381-5p ; hsa-mir-6811-3p ; hsa-mir-214-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-6722-5p ; hsa-mir-3135b ; hsa-mir-891b ; hsa-mir-4772-3p ; hsa-mir-6787-3p ; hsa-mir-1304-3p ; hsa-mir-6736-3p ; hsa-mir-6890-3p ; hsa-mir-216a-5p ; hsa-mir-665 ; hsa-mir-510-3p ; hsa-mir-7160-5p ; hsa-mir-4722-5p ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-4768-3p ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-34b-3p ; hsa-mir-4443 ; hsa-mir-7847-3p ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-7107-3p ; hsa-mir-6753-3p ; hsa-mir-6503-5p ; hsa-mir-4527 ; hsa-mir-4455 ; hsa-mir-6772-5p ; hsa-mir-5787 ; hsa-mir-4505 ; hsa-mir-5589-5p ; hsa-mir-3663-5p ; hsa-mir-6776-5p ; hsa-mir-6504-5p ; hsa-mir-3064-5p ; hsa-mir-149-5p ; hsa-mir-664a-5p ; hsa-mir-4794

Nearest miRNA

hsa-mir-10397/Upstream/1935192; hsa-mir-103a-1/Downstream/523158;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/515, chr5-CpG: 170/Downstream/63946

Upstream sequence

TGTGCTTGTATTTAATGATTTACTAATAAGTGAGTTACAACATCTTTTTTACTTCAGATTAAGACAGTTTGTTTCGTCATGTTACCTTAAggcagtctct

Downstream sequence

AACAGTTTTTGAAACTTTCCCAAGCCAAAGGTGCTACTGTCAACCTTACGCGATGCTTTTAGGATGATCCATGTTTTAAAAAGTGCTGCTTAGACAATTG