Basic Information
VIS ID
TVIS10005037
Fusion event
HBV-LOC107986454 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1792
Orient
+
Integrated sequence
ACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAA| |ATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGC
Host Sequence
Chromosome
chr5
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
141201649/141822084 (Hg38)
End
141201649/141822084 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC107986454
Nearest miRNA
hsa-mir-10397/Upstream/1174158; hsa-mir-103a-1/Downstream/1857776;
Nearest TSS
ENST00000502646/Upstream/139863; ENST00000506775/Downstream/4241;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/68313, chr5-CpG: 102/Downstream/27281
Upstream sequence
tggcctctggttgcataactcctaaacaataatttctaatcttgaggctaatttgttagtcttacaaaggcagtctggtccccaagcaagaagggggttt
Downstream sequence
AAATAATAATAATTTACACAAAGCTCATCCCCAAACAGAAGAGAATCTGTACATAAAAATAAACAAAAATTAAACTGAGCTGGGCCTGGTGCCCAGAAAA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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