PPP2R2B _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005040
Fusion event
HBV-PPP2R2B integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1963
Orient
-
Integrated sequence
TCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTTCT| |GACTTCTTTCCTTCTATTCGAGATCTCCTCGACACCGCCTCTGCTCTGTATCGGGAGGCCTTAGAGTCTCCGGAACATTGTTCACCTCACCATACAGCAC
Host Sequence
Chromosome
chr5
Cytoband
q32
Reference genome
GRCh37/hg19
Start
146039399/146659836 (Hg38)
End
146039399/146659836 (Hg38)
Orient
-
Location type
Intron
Target gene
PPP2R2B
miRNAs that regulate target gene
hsa-mir-30e-3p ; hsa-mir-6825-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-765 ; hsa-mir-6804-5p ; hsa-mir-665 ; hsa-mir-4779 ; hsa-mir-4459 ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa
Nearest miRNA
hsa-mir-10397/Upstream/2979865; hsa-mir-103a-1/Downstream/2402477;
Nearest TSS
ENST00000502646/Upstream/59460; ENST00000503975/Downstream/218745;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/211969, chr5-CpG: 97/Downstream/217947
Upstream sequence
TACCTTCCTGTTTGCCTTTCTTAATGTTAGCTTTTAAAAATACTGTTTTATTGTTTGCTCTTAAGCCTTTGTTCTTAAAATTTTACTCTCAGACATTTAT
Downstream sequence
TAACTTCCAATTGTAGAAAAATGGTCCATTCTGAAAGATTGCTTGGGGAAGATTTTCTGACTTTTCTATATTGACTATGAGGTTTTAGCATCTCTTCCAT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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