BMP6 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005045
Fusion event
HBV-BMP6 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1846
Orient
-
Integrated sequence
AGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCA| |TGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTAC
Host Sequence
Chromosome
chr6
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
7842141/7841908 (Hg38)
End
7842141/7841908 (Hg38)
Orient
-
Location type
Intron
Target gene
BMP6
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-22-3p
Nearest miRNA
hsa-mir-3691/Upstream/1672473; hsa-mir-10398/Downstream/2597809;
Nearest TSS
ENST00000381078/Upstream/115111; ENST00000645232/Downstream/47053;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/113033, chr6-CpG: 170/Downstream/67946
Upstream sequence
agaggcagagacagatacagagagagagagagagacaCGCAGGCACCAGAAAGGAGAGAGTGCTCCCCTCCAAGGCTGCGCTGCACCCCTTCCTGGGTGC
Downstream sequence
CTGTTTTCTCATTTTTAGATTTTTTATCTCCTCACATCTTCAAATCTGTGAGCATTTGCCAAGATTCTTCCTTAGTCGTACATATGGGCTCCCAGCATTG
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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