Basic Information
VIS ID
TVIS10005063
Fusion event
HBV-chr8 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1824
Orient
+
Integrated sequence
AAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAA
Host Sequence
Chromosome
chr8
Cytoband
q24.13
Reference genome
GRCh37/hg19
Start
123746235/122733996 (Hg38)
End
123746235/122733996 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA8C ; FRA8E
Nearest miRNA
hsa-mir-12123/Upstream/3408731; hsa-mir-10400/Downstream/481792;
Nearest TSS
ENST00000518652/Upstream/30573; ENST00000607393/Downstream/46764;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/1093847, chr8-CpG: 223/Downstream/46134
Nearby gene
LOC107986904(-176) ;
Upstream sequence
ggctgtactagtttacattcccaccagcagtgtagaagtgttccctgatcactgcatccaggccaacatgtactgttttcttgatttttttcattatggc
Downstream sequence
CTCAACCTGCGCGAGTGGTTTCATAATTCATGCCTGCCCATCAGCAGACAGATTTAGCCTGCTGCCTGCTGAGTCTGAAAATACTGAATATTAAAATATC
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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