Basic Information
VIS ID
TVIS10005074
Fusion event
HBV-PLPPR1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
3037
Orient
-
Integrated sequence
GACCCTGCGTTCGGAGCCAACTCAAACAATCCAGATTGGGACTTCAACCCCAACAAGGATCACTGGCCAGAGGCAAATCAGGTAGGAGCGGGAGCATTCG| |GGCCAGGGTTCACCCCACCACACGGCGGTCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATATTGACAACAGTGCCAGCAGCGCCTCCTCCTGCCTCCAC
Host Sequence
Chromosome
chr9
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
104086137/101323855 (Hg38)
End
104086137/101323855 (Hg38)
Orient
-
Location type
Intron
Target gene
PLPPR1
Nearest miRNA
hsa-let-7a-1/Upstream/3094638; hsa-mir-12126/Downstream/5277073;
Nearest TSS
ENST00000422679/Upstream/54053; ENST00000615466/Downstream/47620;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/294373, chr9-CpG: 49/Downstream/74716
Upstream sequence
GGCCTTCAGAGAGGTAATGGGCTGTCGGTGGAGGTTTGGGGGCTCTGGAGAGGGAGGCTGGCTGTGTTCCAGGGGCTGCCCAGGAGAGCCACGTGCTCTC
Downstream sequence
aaaCCAAAGAGGTAAGGGAAATTCAGGGGCCTTGGAAAAGCATATTAGGGGGACGGAACAGCCTGTGTACCCTTGAGGAGACAAAACAAGGGAATATTTA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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