WDR5 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005078
Fusion event
HBV-WDR5 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1817
Orient
+
Integrated sequence
TTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGC| |AACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTA
Host Sequence
Chromosome
chr9
Cytoband
q34.2
Reference genome
GRCh37/hg19
Start
137000600/134135478 (Hg38)
End
137000600/134135478 (Hg38)
Orient
-
Location type
Promoter
Target gene
WDR5
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-484 ; hsa-mir-30c-5p ; hsa-mir-3189-5p ; hsa-mir-5699-5p ; hsa-mir-4758-3p ; hsa-mir-6865-3p
Nearest miRNA
hsa-let-7a-1/Upstream/1083419; hsa-mir-126/Downstream/243933;
Nearest TSS
ENST00000422679/Upstream/101; ENST00000358625/Downstream/171;
Nearest CpG islands
chr9-CpG: 171/Target, None/Upstream, None/Downstream
Upstream sequence
agtgttcctaaggcacatcatagccttatggagaaaatgtgtgataggtaaacttaattcaggcataagttacagtgctgttggctgtgagttcaatgtt
Downstream sequence
AAGAGCCCCCAGCCCGGCAGCCGGCCCCGCGGGAAGGCGCAGCCCGGGCTTCCGAACCCTGTGAACGCGCAGGTTCCTGGTCTTCCAGATGGGCAGGAAT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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