Basic Information
VIS ID
TVIS10005084
Fusion event
HBV-chrY integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1615
Orient
-
Integrated sequence
ACCACGGGGCGCACCTCTCTTTACGCGGTCTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGAC| |CACCGTGAACGCCCACCAGGTCTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGAC
Host Sequence
Chromosome
chrY
Cytoband
q11.223
Reference genome
GRCh37/hg19
Start
21856791/19694905 (Hg38)
End
21856791/19694905 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12120/Upstream/6215639;
Nearest TSS
ENST00000430575/Upstream/299; ENST00000465253/Downstream/14044;
Nearest CpG islands
None/Target, chrY-CpG: 62/Upstream/127235, chrY-CpG: 16/Downstream/881034
Upstream sequence
CCCTATGACAGCTTGATGGCTCTTGCTGACTTCCTCACTGCTTAAGAAGATATTATGTCCCTGTCCAGAAGTTGACCCTATAAACATAGACCTGGCCATG
Downstream sequence
ccctgtgctctcaggtgatatatgatttgactatttctttgtctcctgcttttagcctaatttgtattttagtgagccctctttactacctgactggttg
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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