Basic Information
VIS ID
TVIS10005089
Fusion event
HBV-chr1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1826
Orient
+
Integrated sequence
GGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATT
Host Sequence
Chromosome
chr1
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
102914906/102449350 (Hg38)
End
102914906/102449350 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/2168042; hsa-mir-11399/Downstream/5447873;
Nearest TSS
ENST00000473358/Upstream/59720; ENST00000414923/Downstream/404492;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1212161, chr1-CpG: 85/Downstream/1076120
Upstream sequence
AATTGTTATTCGATATTTTCACAAGCAGTTATGTTTCCTCTATAATAATCATTAACTGATAATAATGAATTGGTTAATTAGTTCACTATTCTAGAATATA
Downstream sequence
ACTAAGCATAATTTATTCGTTAACTTTGCATATGATCACTAACAAAAAACCTAGATCTCATTGGATAAAATAATTAATCATAGGATAGTTATAATTTCAT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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