Basic Information
VIS ID
TVIS10005090
Fusion event
HBV-chr1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
2082
Orient
-
Integrated sequence
GAGATCTCCTCGACACCGCCTCTGCTCTGTATCGGGAGGCCTTAGAGTCTCCGGAACATTGTTCACCTCACCATACAGCACTCAGGCAAGCTATTCTGTG| |TTGGGGTGAGTTGATGAATCTGGCCACCTGGGTGGGAAGTAATTTGGAAGACCCAGCATCCAGGGAATTAGTAGTCAGCTATGTCAATGTTAATATGGGC
Host Sequence
Chromosome
chr1
Cytoband
p21.1
Reference genome
End
102914909/102449353 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/2168045; hsa-mir-11399/Downstream/5447870;
Upstream sequence
TGTTATTCGATATTTTCACAAGCAGTTATGTTTCCTCTATAATAATCATTAACTGATAATAATGAATTGGTTAATTAGTTCACTATTCTAGAATATAACT
Downstream sequence
AAGCATAATTTATTCGTTAACTTTGCATATGATCACTAACAAAAAACCTAGATCTCATTGGATAAAATAATTAATCATAGGATAGTTATAATTTCATAGC
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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