KCNT2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005091
Fusion event
HBV-KCNT2 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1817
Orient
+
Integrated sequence
TTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGC| |AACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTA
Host Sequence
Chromosome
chr1
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
196285779/196316649 (Hg38)
End
196285779/196316649 (Hg38)
Orient
+
Location type
Intron
Fragile sites / regions
FRA1K
Target gene
KCNT2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-4452 ; hsa-mir-183-3p ; hsa-mir-4775 ; hsa-mir-500a-5p
Nearest miRNA
hsa-mir-101-1/Upstream/3180066; hsa-mir-1182/Downstream/265764;
Nearest TSS
ENST00000473358/Upstream/255576; ENST00000496761/Downstream/111558;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/3194555, chr1-CpG: 24/Downstream/291929
Upstream sequence
TTGGTTCTACACAACCAAGAGCATATAAAATATACAAATTCTGTTGTATGCAAGCCTACTGTTTAGCCAGCCTAAGTTTTTGAGCAAGTGATTGAATAAC
Downstream sequence
CCGATTTCTTTGGCTGGATGAAGTAATTGCTAAAGTAGGAAACACATACCTGTGAGCTAAAATAGAGTCAGTCTTCTTCCCTATCACTGACAAAAAAAAA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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