Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005104
Fusion event
HBV-TTLL5 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
1816
Orient
-
Integrated sequence
GTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGT
Host Sequence
Chromosome
chr14
Cytoband
q24.3
Reference genome
Start
End
76143854/75677511 (Hg38)
Orient
-
Location type
Intron
Target gene
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-4668-5p ; hsa-mir-3148 ; hsa-mir-3121-3p ; hsa-mir-548c-3p ; hsa-mir-143-5p ; hsa-mir-3944-5p ; hsa-mir-107 ; hsa-mir-103a-3p ; hsa-mir-7157-3p ; hsa-mir-5008-3p ; hsa-mir-6737-3p ; hsa-mir-6889-3p ; hsa-mir-545-5p ; hsa-mir-7845-5p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-4475
Nearest miRNA
hsa-mir-208a/Upstream/1197307; hsa-mir-1185-1/Downstream/1588707;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/15940, chr14-CpG: 76/Downstream/304769
Upstream sequence
ttgagacagggtctcaccctgtcactcaggctggagtgcagtggcctgatcatgactcactgcagccttagcctttcaaggctcaggtgatcctcctgcc
Downstream sequence
tcagcctcccaggtagctgggactacaggcgcacagcaccatgcctggctaaattttgtatttttagtagagatggggtttcaccatgtttcccaggctg
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).