Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005106
Fusion event
HBV-TTBK2 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
1861
Orient
-
Integrated sequence
AGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACT| |GTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTT
Host Sequence
Chromosome
chr15
Cytoband
q15.2
Reference genome
Start
End
43086291/42794093 (Hg38)
Orient
+
Location type
Intron
Target gene
Nearest miRNA
hsa-mir-1233-1/Upstream/594427; hsa-mir-10393/Downstream/999566;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/56672, chr15-CpG: 88/Downstream/126125
Upstream sequence
cagcctctaactcctgggctcaagtgatccttctgcctcagcattttgggtaTTTACCTTTTTTTTTTTTGACCAAAAAGTTTGAAACAACCAAAGCAGG
Downstream sequence
TaaaaaattagaaaaaaaaaaaagacaaataaaaaaacaaaataaaagacaaaaGGAACTCTAATACACGTAGAGGAAAAAACATTAACAATAAAAAACT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).