VISDB Viral Integration Site DataBase

VIS ID

TVIS10005108

Fusion event

HBV-MAZ integration

Validated

No

Detection method

PCR and Ultra-deep sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Start

1874

Orient

+

Integrated sequence

AGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCA| |AGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTTCTGACTTCTTTCC

Chromosome

chr16

Cytoband

p11.2

Reference genome

Start

End

29818794/29807473 (Hg38)

Orient

+

Location type

Promoter MAZ,exon

Target gene

miRNAs that regulate target gene

hsa-mir-148b-3p ; hsa-mir-124-3p ; hsa-mir-122-5p ; hsa-mir-1180-3p ; hsa-mir-877-3p ; hsa-mir-615-3p ; hsa-mir-193b-3p ; hsa-mir-324-5p ; hsa-mir-326 ; hsa-mir-222-3p ; hsa-mir-181a-5p ; hsa-mir-30d-5p ; hsa-mir-615-5p ; hsa-mir-92a-1-5p ; hsa-mir-30b-3p ; hsa-mir-149-3p ; hsa-mir-296-3p ; hsa-mir-887-5p ; hsa-mir-1249-5p ; hsa-mir-3670 ; hsa-mir-3689a-3p ; hsa-mir-3689b-3p ; hsa-mir-4425 ; hsa-mir-3689c ; hsa-mir-4728-5p ; hsa-mir-4733-3p ; hsa-mir-4795-5p ; hsa-mir-6511a-3p ; hsa-mir-6511b-3p ; hsa-mir-6753-5p ; hsa-mir-6761-5p ; hsa-mir-6779-5p ; hsa-mir-6780a-5p ; hsa-mir-6785-5p ; hsa-mir-6797-5p ; hsa-mir-6823-5p ; hsa-mir-6883-5p ; hsa-mir-1273h-5p ; hsa-mir-34a-5p ; hsa-mir-34c-5p ; hsa-mir-449a ; hsa-mir-604 ; hsa-mir-647 ; hsa-mir-449b-5p ; hsa-mir-3150b-3p ; hsa-mir-4784 ; hsa-mir-5693 ; hsa-mir-6732-5p ; hsa-mir-6758-5p ; hsa-mir-6762-3p ; hsa-mir-6835-5p ; hsa-mir-6856-5p ; hsa-mir-7112-5p ; hsa-mir-331-3p ; hsa-mir-651-3p ; hsa-mir-875-3p ; hsa-mir-3148 ; hsa-mir-4308 ; hsa-mir-6124 ; hsa-mir-6835-3p ; hsa-mir-29a-3p ; hsa-mir-29b-3p ; hsa-mir-29c-3p ; hsa-mir-27a-5p ; hsa-mir-6862-5p ; hsa-mir-4253 ; hsa-mir-3622b-5p ; hsa-mir-600 ; hsa-mir-4797-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-6799-5p ; hsa-mir-7106-5p ; hsa-mir-1226-3p ; hsa-mir-4668-5p ; hsa-mir-4469 ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-6861-3p ; hsa-mir-483-3p ; hsa-mir-6749-3p ; hsa-mir-5010-3p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-6796-5p ; hsa-mir-421 ; hsa-mir-7159-5p ; hsa-mir-644a ; hsa-mir-3911 ; hsa-mir-6742-5p ; hsa-mir-4472 ; hsa-mir-4447 ; hsa-mir-3151-5p ; hsa-mir-491-5p ; hsa-mir-5087 ; hsa-mir-7704 ; hsa-mir-4748 ; hsa-mir-4464 ; hsa-mir-505-3p ; hsa-mir-198 ; hsa-mir-204-3p ; hsa-mir-2114-5p ; hsa-mir-365a-5p ; hsa-mir-365b-5p ; hsa-mir-4292 ; hsa-mir-4524b-3p ; hsa-mir-4646-5p ; hsa-mir-4652-5p ; hsa-mir-4685-5p ; hsa-mir-4747-5p ; hsa-mir-4761-3p ; hsa-mir-5196-5p ; hsa-mir-6752-3p ; hsa-mir-6760-3p ; hsa-mir-676-5p ; hsa-mir-6791-5p ; hsa-mir-6801-3p ; hsa-mir-6810-3p ; hsa-mir-6837-5p ; hsa-mir-7113-5p ; hsa-mir-7-5p

Nearest miRNA

hsa-mir-1225/Upstream/208208; hsa-mir-11401/Downstream/696446;

Nearest TSS

Nearest CpG islands

chr16-CpG: 267/Target, None/Upstream, None/Downstream

Upstream sequence

AAGGAGTTCAAGAACGGCTACAATCTCCGGAGGCACGAAGCCATCCACACGGGAGCCAAGGCCGGCCGGGTCCCCTCGGGTGCTATGAAGATGCCGACCA

Downstream sequence

TGGTGCCCCTGAGCCTCCTGAGCGTGCCCCAGCTGAGCGGAGCCGGCGGGGGAGGGGGAGAGGCGGGTGCCGGCGGCGGCGCTGCCGCAGTGGCCGCCGG