Basic Information
VIS ID
TVIS10005117
Fusion event
HBV-chr2 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1822
Orient
-
Integrated sequence
TTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAG
Host Sequence
Chromosome
chr2
Cytoband
p25.3
Reference genome
GRCh37/hg19
Start
1760062/1756290 (Hg38)
End
1760062/1756290 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10b/Downstream/4218372;
Nearest TSS
ENST00000437798/Upstream/11438; ENST00000638236/Downstream/39235;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/11444, chr2-CpG: 60/Downstream/41556
Upstream sequence
TAAATGGATGATGATGGAGCTTCCCCACAGAGAGAAGAACTAAGGCTTTGGATGCTTGGAGCAGATATTTCCATTATTATTAAGTTTGTTTTTTTGTGGA
Downstream sequence
TTTAATTAGTACTTATTCAAACTCCATTCGTGATCTGTCATACTGCTCCCTCAAAGCCTAATTGGTTTTCTACATAAAATGTCACATAGTCTTACATCCA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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