Fusion event
HBV-FN1 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
TCCAGGGAATTAGTAGTCAGCTATGTCAATGTTAATATGGGCCTAAAAATCAGACAACTATTGTGGTTTCACATTTCCTGTCTTACTTTTGGAAGAGAAA| |CTGTTCTTGAGTATTTGGTGTCTTTTGGAGTGTGGATTCGCACTCCTCCCGCTTACAGACCACCAAATGCCCCTATCTTATCAACACTTCCGGAAACTAC
End
216250530/215385807 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-10b/Upstream/1627648; hsa-mir-1244-1/Downstream/2514706;
Upstream sequence
aagaacaatgacactattacCCTAAAATTATATTTTTAAAGGTACTTTGAAACAGTGTTCAGTTTTCCACCttttttttttttttttttgagacagagtc
Downstream sequence
tccctctgtcaccaggctggagtgcagtgacacaatcttggcttactgcaacctccgcctcctgggttcaagcaattctcctgcctcagcctcctgagta
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).