Fusion event
HBV-FLNB integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
TCTGTATCGGGAGGCCTTAGAGTCTCCGGAACATTGTTCACCTCACCATACAGCACTCAGGCAAGCTATTCTGTGTTGGGGTGAGTTGATGAATCTGGCC| |ACCTGGGTGGGAAGTAATTTGGAAGACCCAGCATCCAGGGAATTAGTAGTCAGCTATGTCAATGTTAATATGGGCCTAAAAATCAGACAACTATTGTGGT
End
58045071/58059344 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-let-7g/Upstream/2206750; hsa-mir-12124/Downstream/2558461;
Upstream sequence
TGTACAAACTGCTTAATTCTCATATTTACGTATTCCAATGCAACATTACATAAGAAATAAGGACTATTAGAGGTATTAATTAGATAATTTGGTAAAGTAA
Downstream sequence
tttagtaaataggccaggtggtaAGAGGAGAGAGCCTTGTCTGTGAGTGTGGTCTAGGGGGATGCTGGACCTAGCTTTTCAGAGCTAGGTTCAGGCAGAG
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).