Fusion event
HBV-chr3 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
GGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGG| |GAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTC
End
96129672/96410828 (Hg38)
Nearest miRNA
hsa-let-7g/Upstream/50789; hsa-mir-12124/Downstream/3553486;
Upstream sequence
aaaaatagagatgataagacaggcagaatgggctctttctgacaaaaagacaccaagttataaacaagacctaaggccactgcaggcaaaagttacatca
Downstream sequence
tttttctttctatcacataatcaggctgcaaatttttcaaacttttgcaatctttcatctcttgaatgctttgctgcttggaaatttcctccaccagata
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).