Basic Information
VIS ID
TVIS10005135
Fusion event
HBV-LINC02006 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1826
Orient
+
Integrated sequence
GGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATT
Host Sequence
Chromosome
chr3
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
153385731/153667942 (Hg38)
End
153385731/153667942 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA3D
Target gene
LINC02006
Nearest miRNA
hsa-let-7g/Upstream/2101947; hsa-mir-1224/Downstream/5614704;
Nearest TSS
ENST00000440867/Upstream/183447; ENST00000463297/Downstream/213584;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/504645, chr3-CpG: 131/Downstream/453056
Upstream sequence
atacaagggagatttagttacctgtaatgttatattttttgatgcaggtgctattttcatgggtatgctcacttagtacaaagtgtttgagttgaactca
Downstream sequence
AAAATTCTTTTTTATTTCCTAAATAGAAAAACTAAGACCTTATATCTTTAATTTATCAAAAGTCTGATTTATGTTTCTCATACTGCATTTGTACTTCTTA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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