Basic Information
VIS ID
TVIS10005137
Fusion event
HBV-TRMT44 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1827
Orient
+
Integrated sequence
GACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTT
Host Sequence
Chromosome
chr4
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
8498243/8496516 (Hg38)
End
8498243/8496516 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4A
Target gene
TRMT44
Nearest miRNA
hsa-mir-378d-1/Upstream/491135; hsa-mir-12113/Downstream/1059652;
Nearest TSS
ENST00000502981/Upstream/14246; ENST00000382488/Downstream/10312;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/55130, chr4-CpG: 114/Downstream/83970
Upstream sequence
CAGGAGTCATGTGACTACTAAAAGGTCATGGCACTGATTTTGAAAAAAATATTGCTCTAATTTGATCCTTAGCAATCCAAATTAGAACTACCAAGAATCT
Downstream sequence
GACTGTCGGTTGCTACAGGGCACTTGACAGTAGAAAGACCTCTGGGCAGTTAACCAGAGGCAGCTCCTCTAAATGAGATGCAGAGGTCCCCAAGAAGGAA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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