hsa-mir-6751-3p _LIHC.png
CD109 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005145
Fusion event
HBV-CD109 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1820
Orient
+
Integrated sequence
GTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAAC| |TTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAA
Host Sequence
Chromosome
chr6
Cytoband
q13
Reference genome
GRCh37/hg19
Start
74523390/73813667 (Hg38)
End
74523390/73813667 (Hg38)
Orient
+
Location type
Intron
Fragile sites / regions
FRA6D
Target gene
CD109
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-4482-3p ; hsa-mir-6807-5p ; hsa-mir-6751-3p ; hsa-mir-1199-5p ; hsa-mir-449b-3p ; hsa-mir-103a-2-5p ; hsa-mir-3124-3p ; hsa-mir-186-3p
Nearest miRNA
hsa-mir-10398/Upstream/845914; hsa-mir-10524/Downstream/1614740;
Nearest TSS
ENST00000381078/Upstream/21012; ENST00000421318/Downstream/255784;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/117256, chr6-CpG: 28/Downstream/1271497
Upstream sequence
tattctgtacttaactttcaaaatattatttttcttttgcaataaattgcatctcctttgctgtgtgtctctgtttttttatttcttctaCAAAAACAAA
Downstream sequence
attaccctcttttgggtaataaaatactaaactgttggaaataaactgcaagatcttttgaagttccctgagtgagcagTTGAGCTTTATTGCCAAATGT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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