Basic Information
VIS ID
TVIS10005150
Fusion event
HBV-STEAP2-AS1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1837
Orient
-
Integrated sequence
AGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTA| |ATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTG
Host Sequence
Chromosome
chr7
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
89668829/90039515 (Hg38)
End
89668829/90039515 (Hg38)
Orient
+
Location type
Intronic
Target gene
STEAP2-AS1
Nearest miRNA
hsa-mir-10525/Upstream/14124246; hsa-mir-10399/Downstream/2164500;
Nearest TSS
ENST00000635602/Upstream/595541; ENST00000475789/Downstream/83375;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1279546, chr7-CpG: 98/Downstream/79063
Upstream sequence
GTTAAACTTTCCTTTCCCTTTTTTCTCATTAATGAATGATTCTCATGTATTGGAACTCACATTATAATTTTATTAGTTATAATTTGGAAGTGAAGTAGAT
Downstream sequence
TGCTCCAGGTGAATTCAATGACACTTCTGAACTTAGGAAATAAAACAGGACTGCGTTCTTTATAGTAAAAATGGCTTCAGGTTACCTCATCAGTTTCTTT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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