Basic Information
VIS ID
TVIS10005156
Fusion event
HBV-chr8 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2149
Orient
-
Integrated sequence
TCACCATACAGCACTCAGGCAAGCTATTCTGTGTTGGGGTGAGTTGATGAATCTGGCCACCTGGGTGGGAAGTAATTTGGAAGACCCAGCATCCAGGGAA| |TTAGTAGTCAGCTATGTCAATGTTAATATGGGCCTAAAAATCAGACAACTATTGTGGTTTCACATTTCCTGTCTTACTTTTGGAAGAGAAACTGTTCTTG
Host Sequence
Chromosome
chr8
Cytoband
q24.12
Reference genome
GRCh37/hg19
Start
122396201/121383961 (Hg38)
End
122396201/121383961 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA8C ; FRA8E
Nearest miRNA
hsa-mir-12123/Upstream/2058696; hsa-mir-10400/Downstream/1831827;
Nearest TSS
ENST00000518652/Upstream/470896; ENST00000522197/Downstream/255332;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/571481, chr8-CpG: 64/Downstream/255464
Nearby gene
RPL35AP19(-3431) ;
Upstream sequence
aggccttcccagctatgtggaactctgagtcaactaagcctcttttctttttaaattacccagtctcaggtattctttataagttaaaatggactaatgc
Downstream sequence
CCAACTAGAAGTCAGCATTTTTTGGAGTTAATTTAGATTTCCAAGGATATTTCCCAAAATTGCCATGAGATTCATTACTCAATATGCAAGAAAAATTAAT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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