Basic Information
VIS ID
TVIS10005163
Fusion event
HBV-chrX integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1827
Orient
+
Integrated sequence
GACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTT
Host Sequence
Chromosome
chrX
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
106774075/107530845 (Hg38)
End
106774075/107530845 (Hg38)
Orient
+
Location type
Intronic
Target gene
FRMPD3 ; FRMPD3-AS1
miRNAs that regulate target gene
hsa-mir-3688-5p ; hsa-mir-876-3p ; hsa-mir-323a-5p ; hsa-mir-885-3p ; hsa-mir-335-3p ; hsa-mir-2355-5p ; hsa-mir-4673 ; hsa-mir-4645-5p ; hsa-mir-4692 ; hsa-mir-4514 ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-197-3p ; hsa-mir-3166 ; hsa-mir-6511b-3p ; hsa-mir-6511a-3p ; hsa-mir-603 ; hsa-mir-8485
Nearest miRNA
hsa-let-7f-2/Upstream/890949; hsa-mir-105-1/Downstream/2524484;
Nearest TSS
ENST00000429181/Upstream/4199; ENST00000477796/Downstream/13738;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/23213, chrX-CpG: 22/Downstream/97546
Junction sequence
TA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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