Basic Information
VIS ID
TVIS10005171
Fusion event
HBV-chr1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
1292
Orient
-
Integrated sequence
CAACCCCCACTGGATGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCAGCTTG| |TTTTGCTCGCAGCCGGTCTGGAGCAAAACTTATCGGGACTGACAACTCTGTTGTCCTCTCTCGGAAATACACCTCCTTCCCATGGCTGCTCGGGTGTGCT
Host Sequence
Chromosome
chr1
Cytoband
q44
Reference genome
End
248878329/248715028 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
Nearest miRNA
hsa-mir-101-1/Upstream/1512968; hsa-mir-3124/Downstream/111349;
Nearby gene
AHCYP8(+6965) ;
Upstream sequence
ttattattattaagtttttgtttgcttaggggaaaaaccaaaattaaaagaatttttttatttaaggttattacatttgtgtatctttccgtatgggctt
Downstream sequence
ttagagtcattgtgacattgagttacagagctttgactcctgggtctaaaaaggacaccaagttctgctaaatcttaaacactgacaggaattaaagcct
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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