hsa-mir-6844 _LIHC.png
WDR70 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005180
Fusion event
HBV-WDR70 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1821
Orient
+
Integrated sequence
TTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACT| |TTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAA
Host Sequence
Chromosome
chr5
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
37662687/37662585 (Hg38)
End
37662687/37662585 (Hg38)
Orient
-
Location type
Intron
Fragile sites / regions
FRA5A
Target gene
WDR70
miRNAs that regulate target gene
hsa-mir-6844 ; hsa-mir-6873-3p ; hsa-mir-9-5p ; hsa-mir-4778-3p ; hsa-mir-7152-3p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-660-3p ; hsa-mir-5193
Nearest miRNA
hsa-mir-10397/Upstream/1514597; hsa-mir-103a-1/Downstream/894917;
Nearest TSS
ENST00000502646/Upstream/183115; ENST00000508730/Downstream/60058;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/283031, chr5-CpG: 51/Downstream/171984
Upstream sequence
TACGTCCTTAAATCACACTCAAACCCCCACATCTGCTTGAAGCAACAGGAATTCGGGTCCAGATAGAAATTACTAGGATTTATCTGCAAGGGAACTCCTA
Downstream sequence
ttcctccatcagcctgttgttgcaatgtggaaatgaggggtgttagatctttttgtttattaggaaaagctggaaatccctaatttttTGAATGCCTGTA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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