Fusion event
HBV-chr4 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
AAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTA| |CTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCC
End
126538134/125616979 (Hg38)
Nearest miRNA
hsa-mir-12113/Upstream/109672; hsa-mir-1305/Downstream/17726481;
Upstream sequence
ATATAATAGGCAACACAGGTTCGTCTAACACAGGTCGGTCTAACACTGGTCCAAGTAATCAATCATCATATCTTAtttcttttctttttcttttttgttt
Downstream sequence
TAGGACATCCATAAAAGtttaataaagattaataattttgaatttttattttCTTTTCATCACTAATTTTTTAAACCTCTACttataaaacaaatttaaa
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).