Basic Information
VIS ID
TVIS10005184
Fusion event
HBV-chr4 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
1859
Orient
+
Integrated sequence
AAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTA| |CTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCC
Host Sequence
Chromosome
chr4
Cytoband
q28.1
Reference genome
End
126538134/125616979 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/109672; hsa-mir-1305/Downstream/17726481;
Upstream sequence
ATATAATAGGCAACACAGGTTCGTCTAACACAGGTCGGTCTAACACTGGTCCAAGTAATCAATCATCATATCTTAtttcttttctttttcttttttgttt
Downstream sequence
TAGGACATCCATAAAAGtttaataaagattaataattttgaatttttattttCTTTTCATCACTAATTTTTTAAACCTCTACttataaaacaaatttaaa
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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