Basic Information
VIS ID
TVIS10005197
Fusion event
HBV-chr12 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1736
Orient
+
Integrated sequence
CTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAG| |GAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCT
Host Sequence
Chromosome
chr12
Cytoband
q24.31
Reference genome
GRCh37/hg19
Start
121368600/120930797 (Hg38)
End
121368600/120930797 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA12E
Nearest miRNA
hsa-let-7i/Upstream/207531; hsa-mir-3612/Downstream/513476;
Nearest TSS
ENST00000382841/Upstream/26426; ENST00000541924/Downstream/47746;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/26164, chr12-CpG: 26/Downstream/47885
Upstream sequence
ATTCaaataatttaattaaaaaaaaaCTAtttatttatttatttgagccagggtctcactctgttgcccaggctggagtgcagtggtacaaccacggctc
Downstream sequence
actgtaacctcgaactcctgggttcaagtgatcctcctgcctcagcctcctgaatagctaggattgcaggtgtgatccactgcacctgTCCCCAAATAGA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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