Basic Information
VIS ID
TVIS10005204
Fusion event
HBV-chr1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
1813
Orient
+
Integrated sequence
ACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACC| |ATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACC
Host Sequence
Chromosome
chr1
Cytoband
p32.3
Reference genome
End
55308113/54842440 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
Nearest miRNA
hsa-mir-12136/Upstream/788286; hsa-mir-101-1/Downstream/383201;
Nearby gene
LEXM(-176) ; DHCR24(+7187) ;
Upstream sequence
AGGGCCTCACTGATGAGGAAACTGCTGACCTCAGGCCATGTCCAGCCATGGGGAACATCGGTTTCACCCCTGAGTCAGCCCTTGTGGGCACCCTTCCCTC
Downstream sequence
ACTGTTTCATGTCAGTGAGAATGGGGGAGCAGGTTGTCCCTAGAGGAGACTGGGATACCACAGTTTCGTCCACAAAGCACACATAATGATAAAAAATACT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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