Fusion event
HBV-chr1 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
ACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACC| |ATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACC
End
55308113/54842440 (Hg38)
Nearest miRNA
hsa-mir-12136/Upstream/788286; hsa-mir-101-1/Downstream/383201;
Upstream sequence
AGGGCCTCACTGATGAGGAAACTGCTGACCTCAGGCCATGTCCAGCCATGGGGAACATCGGTTTCACCCCTGAGTCAGCCCTTGTGGGCACCCTTCCCTC
Downstream sequence
ACTGTTTCATGTCAGTGAGAATGGGGGAGCAGGTTGTCCCTAGAGGAGACTGGGATACCACAGTTTCGTCCACAAAGCACACATAATGATAAAAAATACT
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).