Fusion event
HBV-chr1 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
GGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATT
End
91654597/91189040 (Hg38)
Nearest miRNA
hsa-mir-101-1/Upstream/4831353; hsa-mir-11399/Downstream/2657792;
Upstream sequence
gcttcgtcttgccctccgaaccagtcccaatctgatgagctgggtacctcagttggaaatgcagaaatcacccagcttctgtgttgatctcgctgggagc
Downstream sequence
tgcagactggagctcttcctgtttggccttcttgccagccaccTGCACCTTGACAAGATATTTTAAACAGCAAGAGTATGTTTTTTCTTGTCTAAGAGAA
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).