Basic Information
VIS ID
TVIS10005211
Fusion event
HBV-LINC02774 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1803
Orient
+
Integrated sequence
TACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTT| |CACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATG
Host Sequence
Chromosome
chr1
Cytoband
q44
Reference genome
GRCh37/hg19
Start
244172088/244008786 (Hg38)
End
244172088/244008786 (Hg38)
Orient
-
Location type
Intron
Fragile sites / regions
FRA1I
Target gene
LINC02774
Nearest miRNA
hsa-mir-101-1/Upstream/662531; hsa-mir-3124/Downstream/3193181;
Nearest TSS
ENST00000473358/Upstream/91384; ENST00000622512/Downstream/40153;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/29033, chr1-CpG: 169/Downstream/38946
Upstream sequence
cccatattctatctcccagaagctgctggcctggtgaagagatgaaacaggcttgtaaaggatcggttcaggcactggcttgaagatgatactctgcata
Downstream sequence
tcctccaggaccgtaagtcagtgaccattatatggtactgtgtccctggtaggtagaatacacacatctgggaaccaaaacacagagggaggcacagtcc
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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