Basic Information
VIS ID
TVIS10005215
Fusion event
HBV-chr10 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1876
Orient
-
Integrated sequence
GAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAG| |CTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTTCTGACTTCTTTCCTT
Host Sequence
Chromosome
chr10
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
29635726/29346797 (Hg38)
End
29635726/29346797 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1265/Upstream/1057447; hsa-mir-107/Downstream/198207;
Nearest TSS
ENST00000439456/Upstream/54872; ENST00000375322/Downstream/134858;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/421364, chr10-CpG: 71/Downstream/62636
Upstream sequence
AAACTTTGTTTGTAAAATATAAAGAGAGGATGAGGACCCCTCCTCCAGGATCTCTGTGTGTCTGCCTCTGTCCTAGCACTGACTGCAGTGACACTGCATG
Downstream sequence
TTTACATGACCATCCCTCCACAGAGCACATTTTCCAAAGGGCAGGGCCATGTCTTCCATAACCTGTATTCCCAGTGCCCTACTCATGCCTGGGACAAACA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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