VISDB Viral Integration Site DataBase

VIS ID

TVIS10005221

Fusion event

HBV-PTEN integration

Validated

No

Detection method

PCR and Ultra-deep sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Start

1823

Orient

-

Integrated sequence

TAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTT| |TTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGA

Chromosome

chr10

Cytoband

q23.31

Reference genome

Start

End

89635916/87876159 (Hg38)

Orient

-

Location type

Intron

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-17-5p ; hsa-mir-217 ; hsa-mir-216a-5p ; hsa-mir-214-3p ; hsa-mir-26a-5p ; hsa-mir-21-5p ; hsa-mir-494-3p ; hsa-mir-19a-3p ; hsa-mir-141-3p ; hsa-mir-20a-5p ; hsa-mir-18a-5p ; hsa-mir-19b-3p ; hsa-mir-221-3p ; hsa-mir-222-3p ; hsa-mir-106b-5p ; hsa-mir-29b-3p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-519a-3p ; hsa-mir-519c-3p ; hsa-mir-103a-3p ; hsa-mir-107 ; hsa-mir-22-3p ; hsa-mir-25-3p ; hsa-mir-23a-3p ; hsa-mir-29a-3p ; hsa-mir-23b-3p ; hsa-mir-144-3p ; hsa-mir-106a-5p ; hsa-mir-193b-3p ; hsa-mir-181b-5p ; hsa-mir-182-5p ; hsa-mir-128-3p ; hsa-mir-29c-3p ; hsa-mir-425-5p ; hsa-mir-382-5p ; hsa-mir-92a-1-5p ; hsa-mir-92a-3p ; hsa-mir-32-5p ; hsa-mir-200a-3p ; hsa-mir-130b-3p ; hsa-mir-301a-3p ; hsa-mir-492 ; hsa-mir-20b-5p ; hsa-mir-10b-5p ; hsa-mir-155-3p ; hsa-mir-205-5p ; hsa-mir-429 ; hsa-mir-718 ; hsa-mir-10a-5p ; hsa-mir-92b-3p ; hsa-mir-153-3p ; hsa-mir-26b-5p ; hsa-mir-320a ; hsa-mir-543 ; hsa-mir-376a-5p ; hsa-mir-7856-5p ; hsa-mir-4653-3p ; hsa-mir-4328 ; hsa-mir-34a-3p ; hsa-mir-607 ; hsa-mir-3658 ; hsa-mir-6842-3p ; hsa-mir-3144-3p ; hsa-mir-3671 ; hsa-mir-3653-3p ; hsa-mir-5787 ; hsa-mir-4505 ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-4791 ; hsa-mir-3201 ; hsa-mir-1287-5p ; hsa-mir-7853-5p ; hsa-mir-105-5p ; hsa-mir-4272 ; hsa-mir-889-5p ; hsa-mir-6074 ; hsa-mir-6512-5p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-216b-3p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-548av-3p ; hsa-mir-26a-2-3p ; hsa-mir-26a-1-3p ; hsa-mir-652-5p ; hsa-mir-548as-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-377-3p ; hsa-mir-6826-5p ; hsa-mir-301b-3p ; hsa-mir-130a-3p ; hsa-mir-181a-5p ; hsa-mir-29a-5p ; hsa-mir-142-5p ; hsa-mir-106a-3p ; hsa-mir-106b-3p ; hsa-mir-17-3p ; hsa-mir-20a-3p ; hsa-mir-193a-3p ; hsa-mir-190b ; hsa-mir-370-5p ; hsa-mir-302a-3p ; hsa-mir-301a-5p ; hsa-mir-200a-5p ; hsa-mir-130a-5p ; hsa-mir-181c-5p ; hsa-mir-200c-3p ; hsa-mir-518c-3p ; hsa-mir-638 ; hsa-mir-200c-5p ; hsa-mir-486-5p ; hsa-mir-494-5p ; hsa-mir-744-3p ; hsa-mir-1273g-3p ; hsa-mir-1250-3p ; hsa-mir-155-5p ; hsa-mir-21-3p ; hsa-mir-152-3p

Nearest miRNA

hsa-mir-1265/Upstream/372205; hsa-mir-107/Downstream/1187176;

Nearest TSS

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/11831, chr10-CpG: 61/Downstream/706612

Nearest cancer related gene

PTEN(TSG, No orient, 0)

Junction sequence