Basic Information
VIS ID
TVIS10005222
Fusion event
HBV-MIR5694 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2369
Orient
-
Integrated sequence
GTGTGGATTCGCACTCCTCCCGCTTACAGACCACCAAATGCCCCTATCTTATCAACACTTCCGGAAACTACTGTTGTTAGACGACGAGGCAGGTCCCCTA| |GAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATCCCTTGGACTCATA
Host Sequence
Chromosome
chr10
Cytoband
q26.12
Reference genome
GRCh37/hg19
Start
122515995/120756483 (Hg38)
End
122515995/120756483 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Target gene
MIR5694
Nearest miRNA
hsa-mir-107/Upstream/797891; hsa-mir-202/Downstream/1660482;
Nearest TSS
ENST00000439456/Upstream/158534; ENST00000470052/Downstream/20401;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/298618, chr10-CpG: 32/Downstream/94683
Upstream sequence
attcagtttttcaacacatctactgagtttttcatttctatacttatatttttcatgcccaggatctcccattgtttcttatctgtaactacttgttctT
Downstream sequence
ACTTCGTGTTCAAATATCACTCCTTCCCTTTTAAAAGATATTTACTAGGCTTATTTTAAGTGTCTCTAGTAGATATTTCTTGATATACTGCCTTTCAGGG
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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