Fusion event
HBV-GRIA4 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
AGAGAAACTGTTCTTGAGTATTTGGTGTCTTTTGGAGTGTGGATTCGCACTCCTCCCGCTTACAGACCACCAAATGCCCCTATCTTATCAACACTTCCGG| |AAACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATC
End
105547847/105677120 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-10392/Upstream/1827140; hsa-let-7a-2/Downstream/5670637;
Upstream sequence
ACACTGACTACAGTATTTGTAAAGTACAAAAGTAGCCCtatataatattttcaaataaataaatatGAGTGAAAGAATTAAGATAAAGTTATAACTTTCA
Downstream sequence
CTGTTTTCAAAAGAGTGACAACCAAGTGATCCattttttaaaatttttatttatCTTTAGGAATGTTGCAAAGTTAATAATTAAGCTGTAAACACTTAAA
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).