Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005237
Fusion event
HBV-CD163 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
1802
Orient
+
Integrated sequence
ATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGT| |TCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCAT
Host Sequence
Chromosome
chr12
Cytoband
p13.31
Reference genome
Start
End
7646055/7493459 (Hg38)
Orient
+
Location type
Intron
Target gene
Nearest miRNA
hsa-mir-141/Upstream/529268; hsa-let-7i/Downstream/1746008;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/53025, chr12-CpG: 23/Downstream/134948
Upstream sequence
ctttccaaggaactcactgagctgcggggtggcttatccttcctgtccggtaggatttgatacttactGCAGCAAATCTATTCTGGATGTTTCTTGGTGA
Downstream sequence
CAACAGAGACACCAAAACAGCCTTAAACTGCTTATCTATTTGACTAATTTTAAATGAGAAAAAGTGAACACTGTCTTTCTTCAGTCACTATTATTTGTTT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).