Basic Information
VIS ID
TVIS10005242
Fusion event
HBV-LOC105369890 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1780
Orient
+
Integrated sequence
TGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGG| |CTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGT
Host Sequence
Chromosome
chr12
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
90402420/90008643 (Hg38)
End
90402420/90008643 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12B
Target gene
LOC105369890
Nearest miRNA
hsa-let-7i/Upstream/3263494; hsa-mir-1178/Downstream/4553146;
Nearest TSS
ENST00000382841/Upstream/60950; ENST00000548722/Downstream/99096;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/298355, chr12-CpG: 30/Downstream/945384
Upstream sequence
GGAAAGTACTTTTCCTCACTGTAGTTCTGCAGTACCCAGTTTTATTACCCTCATAAATCTATTAGACACATATTTGTCCATATAAAGGAATTTTTAGAAC
Downstream sequence
AATCATTGTTTCATCATGTATGTTTGGTGTAATATACCTTTCTCATATATTTATGTGGATAAACATTTTATTTTAGTTCCAAGTCTTTCCATTCTAGTTA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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