Basic Information
VIS ID
TVIS10005245
Fusion event
HBV-chr14 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1818
Orient
-
Integrated sequence
TTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTAT
Host Sequence
Chromosome
chr14
Cytoband
q12
Reference genome
GRCh37/hg19
Start
30057025/29587819 (Hg38)
End
30057025/29587819 (Hg38)
Orient
-
Location type
Intron
Target gene
MIR548AI ; PRKD1
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-6740-3p ; hsa-mir-6837-3p ; hsa-mir-942-5p ; hsa-mir-3925-3p ; hsa-mir-766-3p ; hsa-mir-4673 ; hsa-mir-4645-5p ; hsa-mir-34a-5p
Nearest miRNA
hsa-mir-208a/Upstream/1954541; hsa-mir-1185-1/Downstream/1426827;
Nearest TSS
ENST00000550708/Upstream/197473; ENST00000550941/Downstream/9849;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/801956, chr14-CpG: 147/Downstream/339185
Upstream sequence
AGGTATATATGTAAAAAAATCACTCTACTGGTAGATATTTTTCAAGTCATTTTATGCCTTTGGCTCATAATTGGAAAGTTCCTTCTTATTGtataaaata
Downstream sequence
ttcttttattaaaattaaacataattaattCCAGAATCTTAAGTTGAGATTGTTTAGAATGTTAAACCCCAGTGGAGGTTCTGACCACCATAATTCACTT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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