Basic Information
VIS ID
TVIS10005246
Fusion event
HBV-chr14 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1737
Orient
+
Integrated sequence
TTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGG| |AGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTA
Host Sequence
Chromosome
chr14
Cytoband
q12
Reference genome
GRCh37/hg19
Start
30057005/29587799 (Hg38)
End
30057005/29587799 (Hg38)
Orient
+
Location type
Intron
Target gene
MIR548AI ; PRKD1
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-6740-3p ; hsa-mir-6837-3p ; hsa-mir-942-5p ; hsa-mir-3925-3p ; hsa-mir-766-3p ; hsa-mir-4673 ; hsa-mir-4645-5p ; hsa-mir-34a-5p
Nearest miRNA
hsa-mir-208a/Upstream/1954521; hsa-mir-1185-1/Downstream/1426847;
Nearest TSS
ENST00000550708/Upstream/197453; ENST00000550941/Downstream/9869;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/801936, chr14-CpG: 147/Downstream/339205
Junction sequence
ATTCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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