Basic Information
VIS ID
TVIS10005247
Fusion event
HBV-chr14 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2377
Orient
-
Integrated sequence
TCGCACTCCTCCCGCTTACAGACCACCAAATGCCCCTATCTTATCAACACTTCCGGAAACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGA| |ACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATCCCTTGGACTCATAAGGTGGGA
Host Sequence
Chromosome
chr14
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
46045610/45576407 (Hg38)
End
46045610/45576407 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-208a/Upstream/8624016; hsa-mir-1185-1/Downstream/2184588;
Nearest TSS
ENST00000550708/Upstream/8412; ENST00000555246/Downstream/138013;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/322808, chr14-CpG: 30/Downstream/1075258
Nearby gene
LOC105370476(-7346) ;
Upstream sequence
TTAAGGTTTTAGAATGAAGATGTTGTTTCTTGATCTATTTAGAAGCTAATAAAAGAGTTACAAACTTAAGTTTGTTAGTGTCAAGTTATTATTTCGGAAA
Downstream sequence
CTTTTTTTAAGTTTTTAAATTAtttttaatttatgtgggtacatagttggtatatatatttatggggtaaatgagatattttgatatgggcatacagtgc
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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