Basic Information
VIS ID
TVIS10005251
Fusion event
HBV-chr16 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1789
Orient
+
Integrated sequence
CCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCA| |TAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGT
Host Sequence
Chromosome
chr16
Cytoband
q21
Reference genome
GRCh37/hg19
Start
65814405/65780502 (Hg38)
End
65814405/65780502 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/8008150; hsa-mir-11401/Downstream/1421819;
Nearest TSS
ENST00000527434/Upstream/178804; ENST00000568023/Downstream/83282;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/656741, chr16-CpG: 40/Downstream/489880
Upstream sequence
CACACCCTCTCTCACTTCTACCCCTCAGGTGCATGGCCCTTTCCACAACAGTCTCAGTTCTGCTCTGTCACTGTCCCAGGCATCCCCTGGTCTAGGGCAG
Downstream sequence
GGATCTTCTGTCTGGTTCTCCCTCATTCCCTTGGTGGGGGGGGGCCTCCAATCCATCCTCCTACACTGCAGAGGCAGAGGATTTTCTGCACGTGCATTTA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate