Basic Information
VIS ID
TVIS10005252
Fusion event
HBV-chr18 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1818
Orient
-
Integrated sequence
TTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTAT
Host Sequence
Chromosome
chr18
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
31430086/33850122 (Hg38)
End
31430086/33850122 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA18A
Nearest miRNA
hsa-mir-1-2/Upstream/3551162; hsa-mir-122/Downstream/1741615;
Nearest TSS
ENST00000575820/Upstream/244481; ENST00000587528/Downstream/173517;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/271099, chr18-CpG: 45/Downstream/308961
Nearby gene
NOL4(+978) ;
Upstream sequence
tTTCCTTGGTAAATAATCATTAAATAGTGGCTGAGATATCTTAAAGCCCTTTTCACTGAGTATTGTTATTTGTACTACACAATTTAAGATTCAGTGACTT
Downstream sequence
TGTGCTTGCATGTGCTATGGTTATTTCAAGGCACTTTTTATCAGCATGATAAAATAATACATATGTGACAAGAAACTGGTGTTGTATGATAAGCTACCTG
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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