Basic Information
VIS ID
TVIS10005260
Fusion event
HBV-LOC102723739 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1952
Orient
+
Integrated sequence
TGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTT| |TTTTGCCTTCTGACTTCTTTCCTTCTATTCGAGATCTCCTCGACACCGCCTCTGCTCTGTATCGGGAGGCCTTAGAGTCTCCGGAACATTGTTCACCTCA
Host Sequence
Chromosome
chr2
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
38434229/38207087 (Hg38)
End
38434229/38207087 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC102723739
Nearest miRNA
hsa-mir-1301/Upstream/2735601; hsa-mir-10b/Downstream/9170588;
Nearest TSS
ENST00000437798/Upstream/13739; ENST00000457385/Downstream/32503;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/129711, chr2-CpG: 118/Downstream/169340
Upstream sequence
gaccaacacatccaaccaccaccaaaacaatttggcagcttcttaaaatgttaattatacacctaccttgcaactcagtcatttcacttctaagtattta
Downstream sequence
accaaaaggaactaaaatgtacgtgcacacaaagattgcacatgagtgttcttagcagctttatttatgatagcccaaactggaaactatttatcaacag
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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