VISDB - VIS Detail

Expression analysis of TCGA samples

Basic Information

VIS ID

TVIS10005289

Fusion event

HBV-TMEM192 integration

Validated

No

Detection method

PCR and Ultra-deep sequencing

Data source

Curated

Sample type

Nontumor

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

29861854

Virus Sequence

Virus name

HBV

Reference genome

AP011098

Start

1782

Orient

+

Integrated sequence

TCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCT| |GTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGC

Host Sequence

Chromosome

chr4

Cytoband

q32.3

Reference genome

GRCh37/hg19

Start

166001110/165079958 (Hg38)

End

166001110/165079958 (Hg38)

Orient

-

Location type

Intron

Target gene

TMEM192

miRNAs that regulate target gene

hsa-mir-101-3p ; hsa-mir-30a-5p ; hsa-mir-181a-5p ; hsa-mir-4533 ; hsa-mir-1273e ; hsa-mir-4650-3p ; hsa-mir-219b-3p ; hsa-mir-3154 ; hsa-mir-6891-5p ; hsa-mir-302f ; hsa-mir-3173-3p ; hsa-mir-2681-5p ; hsa-mir-582-5p ; hsa-mir-532-5p ; hsa-mir-5197-3p ; hsa-mir-144-3p ; hsa-mir-32-3p ; hsa-mir-4282 ; hsa-mir-6514-3p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-6847-3p ; hsa-mir-6811-3p ; hsa-mir-214-5p ; hsa-mir-4493 ; hsa-mir-5693 ; hsa-mir-3681-3p ; hsa-mir-216a-3p ; hsa-mir-128-3p ; hsa-mir-4733-5p ; hsa-mir-6876-5p ; hsa-mir-4476 ; hsa-mir-3149 ; hsa-mir-5096 ; hsa-mir-6855-5p ; hsa-mir-3170 ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-197-3p ; hsa-mir-411-5p ; hsa-mir-630 ; hsa-mir-6832-5p ; hsa-mir-193b-5p ; hsa-mir-6890-5p ; hsa-mir-1273f ; hsa-mir-3945 ; hsa-mir-6743-5p ; hsa-mir-4688 ; hsa-mir-4496 ; hsa-mir-4694-3p

Nearest miRNA

hsa-mir-12113/Upstream/1986330; hsa-mir-1305/Downstream/306284;

Nearest TSS

ENST00000502981/Upstream/20810; ENST00000511305/Downstream/32896;

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/122664, chr4-CpG: 80/Downstream/32258

Junction sequence

T

* Color: Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence

Reference

Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).