Basic Information
VIS ID
TVIS10005302
Fusion event
HBV-chr5 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1826
Orient
+
Integrated sequence
GGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATT
Host Sequence
Chromosome
chr5
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
76365556/77069731 (Hg38)
End
76365556/77069731 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/4191068; hsa-mir-103a-1/Downstream/5770424;
Nearest TSS
ENST00000502646/Upstream/38829; ENST00000512650/Downstream/4150;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/38685, chr5-CpG: 112/Downstream/7326
Nearby gene
AGGF1(-4497) ; ZBED3(+6946) ;
Upstream sequence
AAATTAGTCACCTTTTTTAAAAAAAAAATCATTTATGGGAGACAACCTCTTTCAGAGCCGTAGATACTGTTATCCTTCATTTTTTTGCCAAACATAAAGT
Downstream sequence
taaagttaaaatataaactaagttcctctaaaagttagtttggtctttgccgaggaatgaacaaggacagcgtggaggatagaagcaagacggagtcagt
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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